7 teams of the research center - CRESS UMR1153


Website ORCHAD

The objective of the ORCHAD team is to study the early life determinants of child development and health with particular focuses on early factors (including growth, nutrition and other lifestyle factors) implicated 1) in the development of obesity and cardiometabolic abnormalities and 2) in other aspects of the child’s health and development, such as sleep, cognition and behaviour. Our ultimate aim is to show that ensuring the conditions of a nurturing and healthy early start in life for all has great potential to reach one major goal of the National Strategy for Health: prioritizing prevention rather than care of chronic diseases.


Our team is the first French group of epidemiologists with a research program entirely devoted to the developmental origin of health and diseases (DOHaD). We have played a pioneering role in the development of this research field in France and have leading positions in the coordination of two French birth cohorts, EDEN (regional: www.eden.vjf.inserm.fr) and Elfe (national: www.elfe-france.fr).


Few examples of our recent results on:

  1. The association between early growth velocity and later blood pressure in childhood https://www.ncbi.nlm.nih.gov/pubmed/27550918
  2. Body Mass Index modelling used to investigate the effect of prenatal smoking on early growth https://www.ncbi.nlm.nih.gov/pubmed/28795415
  3. Energy balance-related behaviours at 2 years in association with subsequent adiposity. https://www.ncbi.nlm.nih.gov/pubmed/27528250
  4. Multidimensionality of the relationship between socio-economic position and dietary patterns in early childhood. https://www.ncbi.nlm.nih.gov/pubmed/26399708
  5. Breastfeeding and polyunsaturated fatty acids in the colostrum and their links with the child cognitive development. https://www.ncbi.nlm.nih.gov/pubmed/28081886
  6. Night awakenings and their relation to behaviour in preschool children. http://dx.doi.org/10.1016/j.sleep.2017.10.008

Find us

Bâtiment Inserm Hôpital Paul Brousse

16 avenue Paul Vaillant-Couturier

F-94807 Villejuif Cedex

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Marie-Aline Charles
Team leader


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Edith Lesieux Potier
Administrative contact


Few recent publications of the team

  • Breastfeeding, Polyunsaturated Fatty Acid Levels in Colostrum and Child Intelligence Quotient at Age 5-6 Years.
    Bernard JY,Armand M,Peyre H,Garcia C,Forhan A,De Agostini M,Charles MA,Heude B
    J. Pediatr. 2017; : doi:10.1016/j.jpeds.2016.12.039
  • Night-waking trajectories and associated factors in French preschoolers from the EDEN birth-cohort.
    Reynaud E,Forhan A,Heude B,de Lauzon-Guillain B,Charles MA,Plancoulaine S
    Sleep Med. 2016; 27-28:59-65 doi:10.1016/j.sleep.2016.09.008
  • Early factors related to carbohydrate and fat intake at 8 and 12 months: results from the EDEN mother-child cohort.
    Yuan WL,Nicklaus S,Lioret S,Lange C,Forhan A,Heude B,Charles MA,de Lauzon-Guillain B
    Eur J Clin Nutr 2017; 71:219-226 doi:10.1038/ejcn.2016.216