7 teams of the research center - CRESS UMR1153


Website ECSTRA

The research activities of ECSTRA team can be considered intermediate between theoretical research in biostatistics, and clinical research using statistical tools previously developed. Most of our research is hospital-linked.

Our research is indeed  :

  • to create innovative tools to best fit the clinical setting in order to improve responses to clinical questions in terms of diagnosis, treatment or prognosis.
  • We also try to better diffuse and explain these innovative approaches so that they could be used properly by clinicians and biologists.

Our main research biostatistical themes concern :

1) Bayesian inference

Our objectives are to propose alternate ways for conducting clinical research, from clinical trials, proposing approaches that better handle the current knowledge on the efficacy or toxicity of a new drug, to diagnostic settings as well as to quality control.

2) Causal inference

We aim at developing valid approaches for analyzing observational data in the clinical epidemiology settings, where specificities regarding the sample size, the prevalence of treatment group, and the binary or censored nature of the outcomes are to be handled.

3) Pronostic models

Our aims are to provide performance measures to assess the prognostic interests of new classification or prognostic marker, to handle missing data problems in such a modeling, and to investigate different modeling strategies for longitudinal and survival data. We also develop multiple imputation techniques to handle missing data with particular interest for cluster data and survival outcomes.

Find us


Hôpital Saint Louis

1 avenue Claude Vellefaux

75011 Paris

User Pic
Sylvie Chevret
Team leader


User Pic
Déborah Azoulay
Administrative contact


Few recent publications of the team

  • Budesonide/Formoterol for Bronchiolitis Obliterans After Hematopoietic Stem Cell Transplantation
    Bergeron A, Chevret S, Chagnon K, Godet C, Bergot E, Peffault de Latour R, Dominique S, de Revel T, Juvin K, Maillard N, Reman O, Contentin N, Robin M, Buzyn A, Socié G, Tazi A
    Am J Respir Crit Care Med 2015; :
  • Complicated grief after death of a relative in the intensive care unit.
    Kentish-Barnes N,Chaize M,Seegers V,Legriel S,Cariou A,Jaber S,Lefrant JY,Floccard B,Renault A,Vinatier I,Mathonnet A,Reuter D,Guisset O,Cohen-Solal Z,Cracco C,Seguin A,Durand-Gasselin J,Éon B,Thirion M,Rigaud JP,Philippon-Jouve B,Argaud L,Chouquer R,Adda M,Dedrie C,Georges H,Lebas E,Rolin N,Bollaert PE,Lecuyer L,Viquesnel G,Léone M,Chalumeau-Lemoine L,Garrouste M,Schlemmer B,Chevret S,Falissard B,Azoulay É
    Eur. Respir. J. 2015; : doi:ERJ-01600-2014
  • Mortality prediction in intensive care units with the Super ICU Learner Algorithm (SICULA): a population-based study.
    Pirracchio R,Petersen ML,Carone M,Rigon MR,Chevret S,van der Laan MJ
    Lancet Respir Med 2015; 3:42-52 doi:S2213-2600(14)70239-5